Manager Keith Millen was unable to give Skuse, who has been out with a toe injury, a run-out in the reserves on Wednesday due to illness while Cisse has only recently resumed training after a troublesome thigh problem.
"There`s a bit of a bug going round at the moment and Cole pulled out of the reserve game, which is a shame as he needed the minutes under his belt and it could set him back a week," said Millen.
"We will keep a close eye on Kalifa and see how he is feeling at the weekend."
Striker Jon Stead did play for the reserves and, after making his return from an ankle injury as a substitute against Doncaster last weekend, will hope to push for a starting role following a goal for the second string.
Source: PA
Source: PA